Age-dependent vulnerability to endotoxemia is associated with reduction of anticoagulant factors activated protein C and thrombomodulin.

@article{Starr2010AgedependentVT,
  title={Age-dependent vulnerability to endotoxemia is associated with reduction of anticoagulant factors activated protein C and thrombomodulin.},
  author={Marlene E. Starr and Junji Ueda and Hitoshi Takahashi and H. Weiler and Charles T. Esmon and Bernard Mark Evers and Hiroshi Saito},
  journal={Blood},
  year={2010},
  volume={115 23},
  pages={4886-93}
}
The protein C (PC) pathway is an important anticoagulant mechanism that prevents thrombosis during the systemic inflammatory response. Thrombomodulin (TM), an endothelial cell membrane receptor, accelerates the conversion of PC to activated protein C (APC), which leads to the down-regulation of thrombin production and fibrin formation. Induction of acute endotoxemia in young and aged mice with a low dose of bacterial endotoxin lipopolysaccharide (LPS, 2.5 mg/kg) caused a high mortality rate in… CONTINUE READING
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