Age-dependent suppression of nocturnal growth hormone levels during sleep deprivation.

  title={Age-dependent suppression of nocturnal growth hormone levels during sleep deprivation.},
  author={Janet M Mullington and Dirk M. Hermann and Florian Holsboer and Thomas Pollm{\"a}cher},
  volume={64 3},
Although the major daily peak in plasma growth hormone (GH) level normally occurs during the early part of nocturnal sleep, it is known that in about one quarter of young healthy men, peaks in circulating human GH occur before sleep onset. Possible factors associated with these nocturnal peaks were investigated in the absence of sleep, including subjectively defined sleepiness, electroencephalographically defined drowsiness and short lapses into sleep, measures of cortisol and temperature… Expand
Adaptation of the 24-h growth hormone profile to a state of sleep debt.
Neither the GH profile nor the distribution of SWA conformed with predictions from acute sleep deprivation studies, indicating that adaptation mechanisms are operative during chronic partial sleep loss. Expand
Night sleep EEG and daytime sleep propensity in adult hypopituitary patients with growth hormone deficiency before and after six months of growth hormone replacement
GH replacement does neither affect night sleep nor daytime sleep propensity in GH deficient hypopituitary adults and GH substitution has no sleep disturbing effect. Expand
Interactions Between Growth Hormone Secretion and Sleep
The sleep-wake transition in the human is generally associated with more pronounced variations in endocrine, metabolic, and other parameters than in other species. Expand
Sleep Characteristics in Children with Growth Hormone Deficiency
The analysis of sleep microstructure by means of CAP, in children with GHD, showed a reduction of transient EEG amplitude oscillations, represented by a significant global decrease in the CAP rate, involving all CAP A phase subtypes. Expand
Diurnal variations and sleep deprivation-induced changes in rat hypothalamic GHRH and somatostatin contents.
Comparisons of the present results with previously reported changes in hypothalamic GHRH mRNA suggest that periods of deep nonrapid eye movement sleep (first portion of the light period and recovery sleep after SD) are associated with intense hypothalamicGHRH release. Expand
The temporal relationship between growth hormone and slow wave sleep is weaker after menopause.
The temporal relationship between GH and SWS in premenopausal women is less robust after menopause and is not improved with HT, according to a randomized, double-blind, placebo-controlled protocol. Expand
Reciprocal interactions between the GH axis and sleep.
  • E. van Cauter, F. Latta, +7 authors G. Copinschi
  • Medicine
  • Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
  • 2004
Preliminary data from a sleep study of adults with GH deficiency using wrist actigraphy for 6 nights at home and polysomnography in the laboratory indeed show decreased total sleep time and increased sleep fragmentation in GH-deficient patients as compared with normal controls. Expand
Sleep Loss Reduces Diurnal Rhythm Amplitude of Leptin in Healthy Men
Evidence that sleep influences the nocturnal leptin profile is provided, and may have implications for the understanding of the role of sleep in metabolic regulation and the aetiologies of obesity and the night eating syndrome. Expand
Endocrinology of Sleep
The goal of this chapter is to review the regulation of the endocrine system during sleep as well as the impact of various endocrine loops upon sleep initiation, maintenance, and architecture. Expand
Endocrine Abnormalities in Narcolepsy
The profound influences of sleep and circadian rhythms on endocrine systems have already been discovered in the late 1960s. Growth hormone secretion, for example, is closely linked to the first hoursExpand


Expression of c-jun, hsp72 and gfap following repeated unilateral common carotid artery occlusion in gerbils—correlates of delayed ischemic injury
The close association between the c-jun and hsp72 mRNA decline and the onset of injury may reflect a more general disruption of the transcription process probably as the consequence of secondary metabolic deterioration. Expand
A reproducible model of thromboembolic stroke in mice
An experimental mouse model of thromboembolic stroke is presented, in which standardized fibrin-rich emboli are injected into the internal carotid artery, and establishes a clinically relevant, reproducible stroke model for the study of molecular mechanisms of ischemic brain injury in genetically engineered mice. Expand
Bähr The superoxide dismutase 1 ( SOD 1 ) G 93 A mutation does not promote neuronal injury after transient focal brain ischemia and optic nerve transection in mice
  • Neuroscience
Dynamics of brain metabolism and gene expression after middle cerebral artery occlusion in mice
  • J . Cereb . Blood Flow Metab .
Hermann Erythropoietin protects from axotomy-induced degeneration of retinal ganglion cells by activating ERK-1
  • Hermann Erythropoietin protects from axotomy-induced degeneration of retinal ganglion cells by activating ERK-1
Hermann Erythropoietin protects from focal cerebral ischemia by a dual mechanism involving both ERK - 1 / - 2 and Akt pathways
Hossmann Hemodynamic and metabolism in stroke-prone spontaneously hypertensive rats before manifestation of brain infarcts
  • Hossmann Hemodynamic and metabolism in stroke-prone spontaneously hypertensive rats before manifestation of brain infarcts