Age-dependent sensitization of cutaneous nociceptors during developmental inflammation

  title={Age-dependent sensitization of cutaneous nociceptors during developmental inflammation},
  author={Michael P Jankowski and Jessica L Ross and Jonathon D Weber and Frank B. Lee and A. T. Shank and Renita C Hudgins},
  booktitle={Molecular pain},
BACKGROUND It is well-documented that neonates can experience pain after injury. However, the contribution of individual populations of sensory neurons to neonatal pain is not clearly understood. Here we characterized the functional response properties and neurochemical phenotypes of single primary afferents after injection of carrageenan into the hairy hindpaw skin using a neonatal ex vivo recording preparation. RESULTS During normal development, we found that individual afferent response… CONTINUE READING


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Differential regulation of TRP channels in a rat model of neuropathic pain

  • S Staaf, S Oerther, G Luca, JP Mattsson, P Ernfors
  • 2009
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