Age-dependent sensitivity of the lamb ductus arteriosus to indomethacin and prostaglandins

  title={Age-dependent sensitivity of the lamb ductus arteriosus to indomethacin and prostaglandins},
  author={Ronald I. Clyman and Françoise Mauray and Abraham M. Rudolph and Michael A. Heymann},
  journal={The Journal of pediatrics},
  volume={96 1},
Endogenous prostaglandins inhibit the ability of the ductus arteriosus to contract in response to oxygen. We studied the effects of endogenous prostaglandins and indomethacin (an inhibitor of endogenous prostaglandin production) on isometric contraction of isolated rings of lamb ductus arteriosus from animals of different gestational ages (98 to 103 days and 136 to 147 days; term is 150 days). Rings from animals at about 100 days' gestation have a significantly larger indomethacin-induced… CONTINUE READING
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