Age-dependent retinal capillary pericyte degeneration in galactose-fed dogs.

  title={Age-dependent retinal capillary pericyte degeneration in galactose-fed dogs.},
  author={Peter F. Kador and Yukio Takahashi and Yoshio Akagi and Karen A Blessing and James Randazzo and Milton Wyman},
  journal={Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics},
  volume={23 1},
The galactose-fed beagle develops diabetes-like microvascular changes that are histologically and clinically similar in appearance to all stages of human diabetic retinopathy. This animal model is extremely useful for evaluating drugs for the treatment of diabetic retinopathy; however, the time required to develop the various retinal lesions (24-72 months for background to the proliferative stage) may be considered prohibitive. Retinal vascular changes begin with an initial degeneration of… CONTINUE READING