Age-dependent rescue by simvastatin of Alzheimer's disease cerebrovascular and memory deficits.

Abstract

Alzheimer's disease (AD) is now established as a progressive compromise not only of the neurons but also of the cerebral vasculature. Increasing evidence also indicates that cerebrovascular dysfunction may be a key or an aggravating pathogenic factor in AD, emphasizing the importance to properly control this deficit when aiming for effective therapy. Here… (More)
DOI: 10.1523/JNEUROSCI.0169-12.2012

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