Age-dependent production of mitochondrial hydrogen peroxide, lipid peroxides and fluorescent pigments in the rat heart

@article{Muscari1990AgedependentPO,
  title={Age-dependent production of mitochondrial hydrogen peroxide, lipid peroxides and fluorescent pigments in the rat heart},
  author={Claudio Muscari and Claudio Marcello Caldarera and C. Richard Guarnieri},
  journal={Basic Research in Cardiology},
  year={1990},
  volume={85},
  pages={172-178}
}
Mitochondria were prepared from hearts of 3-, 14-, 18-, and 24-month-old male Wistar rats. Respiratory control ratio (RCR) values did not change with age in the glutamate or succinate-induced respiration except at 24 months in which RCR values significantly increased with both the substrates. Using still glutamate or succinate as substrates the production of H2O2 was measured in the presence of antimycin. A 70% and 25% increase in H2O2 formation was observed at 14 and 18 months of age… CONTINUE READING