Age-dependent odontogenic lesions in rats after a single i.p. injection of N-nitroso-N-methylurea.


The development of a variety of odontogenic lesions was elicited by a single i.p. injection of N-nitroso-N-methylurea (NMU) at a dose of 150 mg/kg body weight. A total of 190 male Wistar/Furth rats were used in this study. The odontogenic lesions appeared macroscopically, mainly as supernumerary lower incisors, 88 +/- 3.48 (SE) days after administration of… (More)


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