Age-dependent neurotoxicity in rats chronically exposed to low levels of lead: calcium homeostasis in central neurons.


Chronic exposure of rats to low level (1 mg/kg. day) lead ingestion starting at a prenatal age reduced the number of IP3 receptors in ER and reduced the capacity of IP3 to increase Cai2+ in permeabilized neurons obtained from the cerebral cortices. Chronic exposure of adult rats to a comparable dose of lead did not cause these changes. A second stimulation… (More)


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