Age-dependent morphine tolerance development in the rat.

  title={Age-dependent morphine tolerance development in the rat.},
  author={Yan Wang and James Mitchell and Kumi Moriyama and Ki-jun Kim and Manohar Sharma and Guo-xi Xie and Pamela Pierce Palmer},
  journal={Anesthesia and analgesia},
  volume={100 6},
In all age groups, the use of opioids to treat chronic pain conditions has increased, yet the impact of age on opioid tolerance development has not been comprehensively addressed. In this study, we investigated age-related differences in morphine tolerance development in rats. Rats aged 3 wk, 3 mo, 6 mo, and 1 yr were used in the study. Morphine (8 mg/kg) was injected subcutaneously twice each day and its analgesic effect assessed by the change in tail-flick latency using a thermal stimulus 5… CONTINUE READING

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