Age-dependent microdamage removal following mechanically induced microdamage in trabecular bone in vivo.

@article{Waldorff2007AgedependentMR,
  title={Age-dependent microdamage removal following mechanically induced microdamage in trabecular bone in vivo.},
  author={Erik I. Waldorff and Steven A. N. Goldstein and Barbara R Mccreadie},
  journal={Bone},
  year={2007},
  volume={40 2},
  pages={425-32}
}
In order to examine the potential age-related response of trabecular bone to microdamage, a novel animal model utilizing a bone chamber to load existing distal femoral trabecular bone of rats was developed. Fifteen 8-month-old (mature) and fifteen 24-month-old (old) Fischer Brown Norway rats underwent bilateral insertion of the bone chamber. After a 3-week recovery period, one leg per animal underwent damage-inducing loading. Double fluorochrome labeling was used to identify microcracks induced… CONTINUE READING