Age-dependent loss of dentate gyrus granule cells in APP/PS1KI mice.

  title={Age-dependent loss of dentate gyrus granule cells in APP/PS1KI mice.},
  author={M C Cotel and T. A. Bayer and Oliver Wirths},
  journal={Brain research},
Loss of neurons in the hippocampus and other brain regions is, besides the occurrence of plaques and tangles, a neuropathological feature of Alzheimer's disease (AD). In recent years a plethora of transgenic mouse models overexpressing mutant amyloid precursor protein (APP) has been developed, which represent valuable research tools. Whereas extracellular plaque pathology is a common feature of these models, neuronal loss is a rather rare characteristic. In the present study, we quantified the… CONTINUE READING

From This Paper

Topics from this paper.