Age-dependent loss of dentate gyrus granule cells in APP/PS1KI mice.

@article{Cotel2008AgedependentLO,
  title={Age-dependent loss of dentate gyrus granule cells in APP/PS1KI mice.},
  author={M C Cotel and T. A. Bayer and Oliver Wirths},
  journal={Brain research},
  year={2008},
  volume={1222},
  pages={207-13}
}
Loss of neurons in the hippocampus and other brain regions is, besides the occurrence of plaques and tangles, a neuropathological feature of Alzheimer's disease (AD). In recent years a plethora of transgenic mouse models overexpressing mutant amyloid precursor protein (APP) has been developed, which represent valuable research tools. Whereas extracellular plaque pathology is a common feature of these models, neuronal loss is a rather rare characteristic. In the present study, we quantified the… CONTINUE READING

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