Age-dependent levels of 5-methyl-, 5-hydroxymethyl-, and 5-formylcytosine in human and mouse brain tissues.

@article{Wagner2015AgedependentLO,
  title={Age-dependent levels of 5-methyl-, 5-hydroxymethyl-, and 5-formylcytosine in human and mouse brain tissues.},
  author={Mirko Wagner and Jessica Steinbacher and Theo F. J. Kraus and Stylianos Michalakis and Benjamin Hackner and Toni M. Pfaffeneder and Arshan Perera and Markus A. M{\"u}ller and Armin Giese and Hans A. Kretzschmar and Thomas Carell},
  journal={Angewandte Chemie},
  year={2015},
  volume={54 42},
  pages={12511-4}
}
The absolute levels of 5-hydroxymethylcytosine (hmC) and 5-methylcytosine (mC) in human brain tissues at various ages were determined. Additionally, absolute levels of 5-formylcytosine (fC) in adult individuals and cytosine modification levels in sorted neurons were quantified. These data were compared with age-related fC, hmC, and mC levels in mouse brain… CONTINUE READING