Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice.

@article{Ishihara2001AgedependentIO,
  title={Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice.},
  author={Takeshi Ishihara and Bin Zhang and Makoto Higuchi and Yasumasa Yoshiyama and John Q. Trojanowski and Virginia M-Y Lee},
  journal={The American journal of pathology},
  year={2001},
  volume={158 2},
  pages={555-62}
}
Intraneuronal filamentous tau inclusions such as neurofibrillary tangles (NFTs) are neuropathological hallmarks of Alzheimer's disease (AD) and related sporadic and familial tauopathies. NFTs identical to those found in AD brains have also been detected in the hippocampus and entorhinal cortex of cognitively normal individuals as they age. To recapitulate age-induced NFT formation in a mouse model, we examined 12- to 24-month-old transgenic (Tg) mice overexpressing the smallest human brain tau… CONTINUE READING

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Intraneuronal filamentous tau inclusions such as neurofibrillary tangles ( NFTs ) are neuropathological hallmarks of Alzheimer 's disease ( AD ) and related sporadic and familial tauopathies .
Intraneuronal filamentous tau inclusions such as neurofibrillary tangles ( NFTs ) are neuropathological hallmarks of Alzheimer 's disease ( AD ) and related sporadic and familial tauopathies .
NeurofilamentsAnatomic structure is physical part ofCytoskeleton
Moreover , ultrastructurally these lesions contained straight tau filaments comprised of both mouse and human tau proteins but not other cytoskeletal proteins ( eg , neurofilaments , microtubules ) .
Intraneuronal filamentous tau inclusions such as neurofibrillary tangles ( NFTs ) are neuropathological hallmarks of Alzheimer 's disease ( AD ) and related sporadic and familial tauopathies .
Intraneuronal filamentous tau inclusions such as neurofibrillary tangles ( NFTs ) are neuropathological hallmarks of Alzheimer 's disease ( AD ) and related sporadic and familial tauopathies .
Intraneuronal filamentous tau inclusions such as neurofibrillary tangles ( NFTs ) are neuropathological hallmarks of Alzheimer 's disease ( AD ) and related sporadic and familial tauopathies .
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