Age-dependent increment of hydroxymethylation in the brain cortex in the triple-transgenic mouse model of Alzheimer's disease.

@article{CadenaDelCastillo2014AgedependentIO,
  title={Age-dependent increment of hydroxymethylation in the brain cortex in the triple-transgenic mouse model of Alzheimer's disease.},
  author={Carla Elizabeth Cadena-Del-Castillo and Christian Valdes-Quezada and Francisco Carmona-Aldana and Clorinda Arias and Federico Berm{\'u}dez-Rattoni and F{\'e}lix Recillas-Targa},
  journal={Journal of Alzheimer's disease : JAD},
  year={2014},
  volume={41 3},
  pages={845-54}
}
Alzheimer's disease (AD) is a complex disorder whose etiology is associated with environmental and genetic factors. Recently there have been several attempts to analyze the role of epigenetic alterations in the origin and progression of this neurodegenerative condition. To evaluate the potential participation of the methylation status of the genome that may contribute to AD progression, we have studied the levels and distribution of the 5-methylcytosine and 5-hydroxymethylcytosine in different… CONTINUE READING
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