Age-dependent increases in apoptosis/necrosis ratios in human lymphocytes exposed to oxidative stress.

Abstract

Unlike apoptosis, mechanisms leading to necrosis are less well understood. Moreover, changes in necrosis as a function of age have not been studied in human lymphocytes. H(2)O(2)-induced death of peripheral lymphocytes (56 healthy donors, 24-95 years) was evaluated by flow cytometry and propidium iodide staining, caspase activation, DNA laddering, and… (More)
DOI: 10.1093/gerona/glr039

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Cite this paper

@article{Behrens2011AgedependentII, title={Age-dependent increases in apoptosis/necrosis ratios in human lymphocytes exposed to oxidative stress.}, author={Mar{\'i}a Isabel Behrens and M{\'o}nica Silva and Astrid Schmied and Felipe Salech and Hachi E Manzur and Rolando A Rebolledo and Ricardo Bull and Vicente A. Torres and Mauricio Henr{\'i}quez and Andrew F. G. Quest}, journal={The journals of gerontology. Series A, Biological sciences and medical sciences}, year={2011}, volume={66 7}, pages={732-40} }