Age-dependent inability of the endocrine pancreas to adapt to pregnancy: a long-term consequence of perinatal malnutrition in the rat.

@article{Blondeau1999AgedependentIO,
  title={Age-dependent inability of the endocrine pancreas to adapt to pregnancy: a long-term consequence of perinatal malnutrition in the rat.},
  author={Bertrand Blondeau and Angelo Garofano and P Czernichow and B. Breant},
  journal={Endocrinology},
  year={1999},
  volume={140 9},
  pages={
          4208-13
        }
}
We have recently shown that maternal food restriction during late pregnancy decreased beta-cell mass in the offspring at birth. Prolonged maternal malnutrition until weaning led to irreversible decrease of beta-cell mass in the adult male progeny. During pregnancy, the maternal endocrine pancreas demonstrates an acute and reversible increase in beta-cell mass. The aim of this work was to investigate whether perinatal malnutrition could have long-lasting effects on glucose homeostasis and the… CONTINUE READING

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