Age-dependent glomerulosclerosis and proteinuria occurring in rats of the Milan normotensive strain and not in rats of the Milan hypertensive strain.

@article{Brandis1986AgedependentGA,
  title={Age-dependent glomerulosclerosis and proteinuria occurring in rats of the Milan normotensive strain and not in rats of the Milan hypertensive strain.},
  author={A. Brandis and Giuseppe Bianchi and Enrico Reale and Udo M Helmchen and Klaus Kuehn},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1986},
  volume={55 2},
  pages={234-43}
}
The development of an age-dependent glomerulosclerosis and proteinuria was investigated in two strains of rats in a model of moderate hypertension comparing rats of the Milan Hypertensive Strain (MHS) with rats of the Milan Normotensive Strain (MNS). Serum creatinine, urinary protein excretion, renal morphology (light- and electronmicroscopy) and morphometry of the media thickness of the intrarenal arteries and of the thickness of the glomerular basement membrane were studied in 2- to 16-month… CONTINUE READING

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