Age-dependent genetic variants associated with longitudinal changes in brain structure across the lifespan

  title={Age-dependent genetic variants associated with longitudinal changes in brain structure across the lifespan},
  author={Rachel M. Brouwer and Marieke Klein and Katrina L. Grasby and Hugo G. Schnack and Neda Jahanshad and Jalmar Teeuw and Sophia I. Thomopoulos and Emma Sprooten and Carol E. Franz and Nitin Gogtay and William S. Kremen and Matthew S. Panizzon and Loes M. Olde Loohuis and Christopher D. Whelan and Moji Aghajani and Clara Alloza and Dag Aln{\ae}s and Eric Artiges and Rosa Ayesa-Arriola and Gareth J. Barker and Mark E. Bastin and Elisabet Blok and Erlend B{\o}en and Isabella A. Breukelaar and Joanna K. Bright and Elizabeth E. L. Buimer and Robin B{\"u}low and Dara M. Cannon and Simone Ciufolini and Nicolas A. Crossley and Christienne G. Damatac and Paola Dazzan and Casper L de Mol and Sonja M C de Zwarte and Sylvane Desrivi{\`e}res and Covadonga M. D{\'i}az-Caneja and Nhat Trung Doan and Katharina Dohm and Juliane Hilde Fr{\"o}hner and Janik Goltermann and Antoine Grigis and Dominik Grotegerd and Laura K. M. Han and Mathew A. Harris and Catharina A. Hartman and Sarah Heany and Walter Heindel and Dirk J. Heslenfeld and Sarah Hohmann and Bernd Ittermann and Philip R. Jansen and Joost Janssen and Tianye Jia and Jiyang Jiang and Christiane Jockwitz and Temmuz Karali and Daniel Keeser and Martijn G.J.C. Koevoets and Rhoshel K. Lenroot and Berend Malchow and Ren{\'e} C. W. Mandl and Vicente Medel and Susanne Meinert and Catherine A. Morgan and Thomas W. M{\"u}hleisen and Leila Nabulsi and Nils Opel and V{\'i}ctor Ort{\'i}z-Garc{\'i}a de la Foz and Bronwyn J. Overs and Marie-Laure Paill{\`e}re Martinot and Erin Burke Quinlan and Ronny Redlich and Tiago Reis Marques and Jonathan Repple and Gloria M. P. Roberts and Gennady V. Roshchupkin and Nikita Setiaman and Elena Shumskaya and Frederike Stein and Gustavo P. Sudre and Shun Takahashi and Anbupalam Thalamuthu and Diana Tordesillas-Guti{\'e}rrez and Aad van der Lugt and Neeltje E.M. van Haren and Joanna Marguerite Wardlaw and Wei Wen and Henk‐Jan Westeneng and Katharina Wittfeld and Alyssa H. Zhu and Andr{\'e} Zugman and Nicola J. Armstrong and Gaia Bonfiglio and Janita Bralten and Shareefa Dalvie and Gail Davies and Marta di Forti and Linda Ding and Gary Donohoe and Andreas J. Forstner and Javier Gonz{\'a}lez-Pe{\~n}as and Jo{\~a}o P. O. F. T. Guimar{\~a}es and Georg Homuth and Jouke- Jan Hottenga and Maria J. Knol and John B. J. Kwok and St{\'e}phanie Le Hellard and Karen A. Mather and Yuri Milaneschi and Derek W. Morris and Markus M. N{\"o}then and Sergi Papiol and Marcella Rietschel and Marcos Leite Santoro and Vidar M. Steen and Jason L. Stein and Fabian Streit and Rick M Tankard and Alexander Teumer and Dennis van ‘t Ent and Dennis van der Meer and Kristel R. van Eijk and Evangelos Vassos and Javier V{\'a}zquez-Bourgon and Stephanie H. Witt and Hieab H. H. Adams and Ingrid Agartz and David Ames and Katrin Amunts and Ole Andreas Andreassen and Celso Arango and Tobias Banaschewski and Bernhard T. Baune and Sintia Iole Belangero and Arun L. W. Bokde and Dorret I. Boomsma and Rodrigo Affonseca Bressan and Henry Brodaty and Jan K. Buitelaar and Wiepke Cahn and Svenja Caspers and Sven Cichon and Benedicto Crespo Facorro and Simon R. Cox and Udo Dannlowski and Torbj{\o}rn Elvs{\aa}shagen and Thomas Espeseth and Peter G Falkai and Simon E. Fisher and Herta Flor and Janice M. Fullerton and Hugh Garavan and Penny A. Gowland and Hans J{\"o}rgen Grabe and Tim Hahn and Andreas Heinz and Manon H. J. Hillegers and Jacqueline Hoare and Pieter J. Hoekstra and Mohammad Arfan Ikram and Andrea Parolin Jackowski and Andreas Jansen and Erik G. J{\"o}nsson and Ren{\'e} S. Kahn and Tilo T. J. Kircher and Mayuresh S. Korgaonkar and Axel Krug and Herv{\'e} Lema{\^i}tre and Ulrik F. Malt and Jean-Luc Martinot and Colm Mcdonald and Philip B. Mitchell and Ryan L. Muetzel and Robin M. Murray and Frauke Nees and Igor Nenadi{\'c} and Jaap Oosterlaan and Roel A. Ophoff and Pedro Mario Pan and Brenda W.J.H. Penninx and Luise Poustka and Perminder Singh Sachdev and Giovanni Abrah{\~a}o Salum and Peter R. Schofield and Gunter Schumann and Philip Shaw and Kang Sim and Michael N. Smolka and Dan J Stein and Julian N. Trollor and Leonard H. van den Berg and Jan Herman Veldink and Henrik Walter and Lars Tjelta Westlye and Robert A. Whelan and Tonya White and Margaret J. Wright and Sarah E. Medland and Barbara Franke and Paul M. Thompson and Hilleke E. Hulshoff Pol},
Human brain structure changes throughout our lives. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental, and neurodegenerative diseases. Here, we identified common genetic variants that affect rates of brain growth or atrophy, in the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal MRI data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most… 


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