Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency

@article{Shen2008AgedependentEC,
  title={Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency},
  author={Siming Shen and Juan Obreg{\'o}n Sandoval and Victoria A. Swiss and Jiadong Li and Jeffrey L Dupree and Robin J. M. Franklin and Patrizia Casaccia-Bonnefil},
  journal={Nature Neuroscience},
  year={2008},
  volume={11},
  pages={1024-1034}
}
The efficiency of remyelination decreases with age, but the molecular mechanisms responsible for this decline remain only partially understood. In this study, we show that remyelination is regulated by age-dependent epigenetic control of gene expression. In demyelinated young brains, new myelin synthesis is preceded by downregulation of oligodendrocyte differentiation inhibitors and neural stem cell markers, and this is associated with recruitment of histone deacetylases (HDACs) to promoter… CONTINUE READING
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