Age-dependent enhancement of hippocampal long-term potentiation in knock-in mice expressing human apolipoprotein E4 instead of mouse apolipoprotein E.

Abstract

Human apolipoprotein E (apoE) comprises three isoforms, apoE2, apoE3 and apoE4, and apoE4 has been reported as a risk factor of Alzheimer's disease (AD). One of the clinical symptoms of AD is disorder of memory that has been suggested to be related with synaptic plasticity such as long-term potentiation (LTP). Here, we show the enhancement of hippocampal… (More)

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@article{Kitamura2004AgedependentEO, title={Age-dependent enhancement of hippocampal long-term potentiation in knock-in mice expressing human apolipoprotein E4 instead of mouse apolipoprotein E.}, author={Hiroyuki W Kitamura and Hiroki Hamanaka and Masahiko Watanabe and Koji Wada and Chiharu Yamazaki and Shinobu C. Fujita and Toshiya Manabe and Nobuyuki Nukina}, journal={Neuroscience letters}, year={2004}, volume={369 3}, pages={173-8} }