Age-dependent effects of 6-hydroxydopamine on locomotor activity in the rat.

@article{Erinoff1979AgedependentEO,
  title={Age-dependent effects of 6-hydroxydopamine on locomotor activity in the rat.},
  author={Lynda Erinoff and Robert C. Macphail and Alfred Heller and Lewis S. Seiden},
  journal={Brain research},
  year={1979},
  volume={164},
  pages={195-205}
}
This experiment examined the effects on locomotor activity of intraventricular 6-hydroxydopamine (6-OHDA) administered to developing and adult rats. 6-OHDA was administered subsequent to pargyline treatment at 3 and 6 days of age; or 6-OHDA was administered subsequent to desmethylimipramine (DMI) treatment (6-OHDA/DMI) at 3 and 6 days of age, 11 and 14 days of age, 20 and 23 days of age, or 46 and 48 days of age. Locomotor activity of vehicle-treated rats assessed in stabilimeter cages peaked… CONTINUE READING