Age-dependent effect of apolipoprotein E4 on functional outcome after controlled cortical impact in mice.

@article{Mannix2011AgedependentEO,
  title={Age-dependent effect of apolipoprotein E4 on functional outcome after controlled cortical impact in mice.},
  author={Rebekah C. Mannix and Jimmy Zhang and Juyeon Park and Xuan Zhang and Kiran Bilal and Kendall R. Walker and Rudolph E. Tanzi and Giuseppina Tesco and Michael Whalen},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2011},
  volume={31 1},
  pages={351-61}
}
The apolipoprotein E4 (APOE4) gene leads to increased brain amyloid beta (Aβ) and poor outcome in adults with traumatic brain injury (TBI); however, its role in childhood TBI is controversial. We hypothesized that the transgenic expression of human APOE4 worsens the outcome after controlled cortical impact (CCI) in adult but not immature mice. Adult and immature APOE4 mice had worse motor outcome after CCI (P<0.001 versus wild type (WT)), but the Morris water maze performance was worse only in… CONTINUE READING