Age-dependent disruption in hippocampal θ oscillation in amyloid-β overproducing transgenic mice.

@article{Scott2012AgedependentDI,
  title={Age-dependent disruption in hippocampal θ oscillation in amyloid-β overproducing transgenic mice.},
  author={Liam Scott and Jianlin Feng and Tam{\'a}s Kiss and Elie Needle and Kevin Atchison and Thomas T. Kawabe and A. Milici and Eva Haj{\'o}s-Korcsok and David Riddell and Mih{\'a}ly Haj{\'o}s},
  journal={Neurobiology of aging},
  year={2012},
  volume={33 7},
  pages={1481.e13-23}
}
Transgenic mice are used to model increased brain amyloid-β (Aβ) and amyloid plaque formation reflecting Alzheimer's disease pathology. In our study hippocampal network oscillations, population spikes, and long-term potentiation (LTP) were recorded in APPswe/PS1dE9 (APP/PS1) and presenilin1 (PS1) transgenic and wild type mice at 2, 4, and 8 months of age under urethane anesthesia. Hippocampal theta oscillations elicited by brainstem stimulation were similar in wild type and PS1 mice at all age… CONTINUE READING
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