Age-dependent differences in microglial responses to systemic inflammation are evident as early as middle age.


Whereas age increases microglial inflammatory activities and impairs their ability to effectively regulate their immune response, it is unclear at what age these exaggerated responses begin. We tested the hypotheses that augmented microglial responses to inflammatory challenge are present as early as middle age and that repeated stimulation of primed… (More)
DOI: 10.1152/physiolgenomics.00129.2015


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