Age-dependent depletion of human skin-derived progenitor cells.

@article{Gago2009AgedependentDO,
  title={Age-dependent depletion of human skin-derived progenitor cells.},
  author={Nuria Gago and Virginia P{\'e}rez-L{\'o}pez and Juan Pablo Sanz-Jaka and Pedro Cormenzana and I{\~n}aki Eizaguirre and Antonio Bernad and Ander Izeta},
  journal={Stem cells},
  year={2009},
  volume={27 5},
  pages={1164-72}
}
A major unanswered question in autologous cell therapy is the appropriate timing for cell isolation. Many of the putative target diseases arise with old age and previous evidence, mainly from animal models, suggests that the stem/progenitor cell pool decreases steadily with age. Studies with human cells have been generally hampered to date by poor sample availability. In recent years, several laboratories have reported on the existence, both in rodents and humans, of skin-derived precursor (SKP… CONTINUE READING