Age-dependent changes in blood pressure and arterial reactivity in obese Zucker rats.

@article{Subramanian2003AgedependentCI,
  title={Age-dependent changes in blood pressure and arterial reactivity in obese Zucker rats.},
  author={Ramaswamy Subramanian and Kathleen M Macleod},
  journal={European journal of pharmacology},
  year={2003},
  volume={477 2},
  pages={143-52}
}
The purpose of the present investigation was to determine whether there is an association between changes in arterial reactivity to vasoactive agents and the development of hypertension in obese Zucker rats. At 20 weeks of age, obese rats were mildly hypotensive compared to their lean littermate controls. Maximum contractile responses of endothelium-intact mesenteric arteries from these rats to noradrenaline, endothelin-1 and KCl were depressed, although there was no change in relaxation to… CONTINUE READING

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