Age-dependent cerebral atrophy and cognitive dysfunction in SAMP10 mice.

  title={Age-dependent cerebral atrophy and cognitive dysfunction in SAMP10 mice.},
  author={Atsuyoshi Shimada},
  journal={Neurobiology of aging},
  volume={20 2},
Findings obtained from a series of studies to characterize age-dependent changes in brain morphology and behavior of inbred SAMP10 mice are reviewed. Following apparently normal development, SAMP10 mice developed brain atrophy with advancing age. The neocortex was diffusely atrophic in aged SAMP10 mice, with the frontal cortex being most affected. The entorhinal cortex, amygdala, and nucleus accumbens were also atrophic. Other subcortical structures were mildly atrophic, but the hippocampus was… CONTINUE READING
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