Age-dependent and cell-population-restricted LRRK2 expression in normal mouse spleen.

  title={Age-dependent and cell-population-restricted LRRK2 expression in normal mouse spleen.},
  author={Tatsunori Maekawa and Makoto Kubo and Ikue Yokoyama and Etsuro Ohta and Fumiya Obata},
  journal={Biochemical and biophysical research communications},
  volume={392 3},
Leucine-rich repeat kinase 2 (LRRK2) is the causal molecule of familial Parkinson's disease (PD), but its true physiological function remains unknown. In the normal mouse, LRRK2 is expressed in kidney, spleen, and lung at much higher levels than in brain, suggesting that LRRK2 may play an important role in these organs. Analysis of age-related changes in LRRK2 expression demonstrated that expression in kidney, lung, and various brain regions was constant throughout adult life. On the other hand… CONTINUE READING
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