Age-dependent alterations of the hippocampal cell composition and proliferative potential in the hAβPPSwInd-J20 mouse.

@article{Fu2014AgedependentAO,
  title={Age-dependent alterations of the hippocampal cell composition and proliferative potential in the hAβPPSwInd-J20 mouse.},
  author={Yuhong Fu and Zolt{\'a}n Ruszn{\'a}k and John B Kwok and Woojin Kim and George Paxinos},
  journal={Journal of Alzheimer's disease : JAD},
  year={2014},
  volume={41 4},
  pages={
          1177-92
        }
}
The J20 mouse expresses human mutant amyloid-β protein precursor (hAβPPSwInd) and is an established transgenic model of Alzheimer's disease (AD). From the age of 5 months, amyloid-β (Aβ) deposits appear in the hippocampus with concomitant increase of AD-associated features. Although changes occurring after the appearance of Aβ deposits have been extensively studied, very little is known about alterations that occur prior to 5 months. The present study aimed to identify changes in the cellular… CONTINUE READING
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