Age-dependent alterations in synaptic membrane systems for Ca2+ regulation.

  title={Age-dependent alterations in synaptic membrane systems for Ca2+ regulation.},
  author={Mary L. Michaelis and K K Johe and Theresa E Kitos},
  journal={Mechanisms of ageing and development},
  volume={25 1-2},
The effects of aging on two neuronal plasma membrane Ca2+ regulating systems have been examined using synaptic membranes isolated from the brains of adult (5-7-month-old) and aged (23-25-month-old) Fisher 344 rats. The kinetic characteristics of the Na+-dependent Ca2+ transport system were found to be altered in the aged animals. The affinity of the transport carrier for Ca2+ was decreased in membranes from aged animals, with very little change in the maximal transport capacity of the system… CONTINUE READING

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