Age-dependent alterations in fibrillar collagen content and myocardial diastolic function: role of SPARC in post-synthetic procollagen processing.

@article{Bradshaw2010AgedependentAI,
  title={Age-dependent alterations in fibrillar collagen content and myocardial diastolic function: role of SPARC in post-synthetic procollagen processing.},
  author={Amy Dodd Bradshaw and Catalin F. Baicu and Tyler J Rentz and An O Van Laer and David D Bonnema and Michael R. Zile},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2010},
  volume={298 2},
  pages={H614-22}
}
Advanced age, independent of concurrent cardiovascular disease, can be associated with increased extracellular matrix (ECM) fibrillar collagen content and abnormal diastolic function. However, the mechanisms causing this left ventricular (LV) remodeling remain incompletely defined. We hypothesized that one determinant of age-dependent remodeling is a change in the extent to which newly synthesized procollagen is processed into mature collagen fibrils. We further hypothesized that secreted… CONTINUE READING

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