Age-dependent accumulation of ubiquitinated 2',3'-cyclic nucleotide 3'-phosphodiesterase in myelin lipid rafts.

@article{Hinman2008AgedependentAO,
  title={Age-dependent accumulation of ubiquitinated 2',3'-cyclic nucleotide 3'-phosphodiesterase in myelin lipid rafts.},
  author={Jason D Hinman and C. Chen and Sun-Young Oh and William den Hollander and Carmela R. Abraham},
  journal={Glia},
  year={2008},
  volume={56 1},
  pages={
          118-33
        }
}
Changes in brain white matter are prominent features of the aging brain and include glial cell activation, disruption of myelin membranes with resultant reorganization of the molecular components of the node of Ranvier, and loss of myelinated fibers associated with inflammation and oxidative stress. In previous studies, overexpression of CNP, a key myelin protein, was implicated in age-related changes in myelin and axons. Here we examine the extent of CNP accumulation in brain white matter and… CONTINUE READING
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