Age dependent accumulation of cadmium in the human ovary.

@article{Varga1993AgeDA,
  title={Age dependent accumulation of cadmium in the human ovary.},
  author={Bertalan Varga and B{\'e}la Zsolnai and Katalin Paksy and Mikl{\'o}s N{\'a}ray and Gy{\"o}rgy Ungv{\'a}ry},
  journal={Reproductive toxicology},
  year={1993},
  volume={7 3},
  pages={
          225-8
        }
}
Correlation relationship between cadmium accumulation and histological structures of ovary and uterus in rabbits
TLDR
It is reported that with higher cadmium content in ovaries there is lower amount of primary follicles and stroma, but more growing follicles, while on the other hand higher incidence of follicular atresia, which affect mainly growing follicle, is described.
Blood Cadmium Concentrations in Women with Ectopic Pregnancy
TLDR
There was no significant association between blood cadmium levels and ectopic pregnancy.
Cadmium Exposure and Ovarian Reserve in Women Ages 35-49 Years: The Impact on Results of Creatinine Adjustment Approach to Correct for Urinary Dilution.
TLDR
It is concluded that cadmium may contribute to ovarian aging in women and that careful consideration of the creatinine-adjustment approach is needed to minimize bias.
Gestational Cadmium Exposure-Induced Ovotoxicity Delays Puberty through Oxidative Stress and Impaired Steroid Hormone Levels
TLDR
The data generated from the present study suggest that gestational Cd treatment induces ovarian toxicity and reproductive dysfunction through increased oxidative stress.
Effects of in vitro cadmium exposure on ovarian steroidogenesis in rats
TLDR
Cd exposure appears to interfere with the ovarian steroidogenic pathway in rats at more than one site, with productions of P4 and testosterone in proestrus rats and less in pregnant dams, whereas E2 was not affected at all.
Is environmental cadmium a serious hazard to Czech population?
TLDR
The main objective of the study was to asses whether the environmental cadmium exposure in the Czech Republic is high enough to be able to affect significantly the human reproduction and confirmed the previous findings on the low exposure of the Czech population to environmental cadMium.
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An age-dependent increase of Cd, Zn, and Cd/Zn was observed in the kidney; increases peaked at mid-age and were followed by a decline, and no other correlation was found between Cu and MT in either organs.
Cadmium in kidney cortex of inhabitants of North-West Germany: its relationship to age, sex, smoking and environmental pollution by cadmium
SummaryThe cadmium concentration in kidney cortex (CdKc) was determined in 388 deceased persons, who at the time of death had lived in the cities of Düsseldorf and Duisburg, Federal Republic of
Distribution of cadmium in ovaries, adrenals and pituitary gland after chronic administration in rats.
TLDR
CdCl2 even in the dose of 1.0 mg/kg/week failed to alter the ovarian cycle, progesterone and oestradiol-17 beta production of ovary, pointing to a developing tolerance to Cd as the cumulative dose of CdCl 2 lies close to the LD50 levels.
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The data are difficult to interpret with regard to the determination of causality between uptake and disease because of a lack of enough consistent and reliable data on occupation, environment, and smoking habits, and in general due to a lot of variables which, until now, cannot be sufficiently quantified.
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TLDR
The findings suggest that even at environmental exposure levels calcium metabolism is gradually affected, as cadmium accumulates in the body, and the morbidity associated with this phenomenon in industrialised countries remains presently unknown.
Metal-binding proteins of the Syrian hamster ovaries: apparent deficiency of metallothionein.
TLDR
This study was undertaken to define the nature of any such proteins in the Syrian hamster ovary, and found that hamsters were made resistant to cadmium-induced ovarian necrosis by zinc treatment, and Cadmium treatment did not increase the levels of the ovarian metal-binding protein yet markedly induced hepatic metallothionein.
Long-term effects of a single cadmium chloride injection on the ovulation, ovarian progesterone and estradiol-17 beta secretion in rats.
TLDR
CdCl2 shortly after its administration induced a (dose-dependent) anoestrous period which turned into regular or irregular cycles depending on the dose, and when ovulation occurred normal number of ova was found.
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