Age-dependent abnormalities of hematopoietic stem cells in (NZW x BXSB)F1 mice.

  title={Age-dependent abnormalities of hematopoietic stem cells in (NZW x BXSB)F1 mice.},
  author={Akira Sugihara and Yasushi Adachi and Muneo Inaba and Hiroko Hisha and Kikuya Sugiura and Shunsuke Miyashima and Yasuo Amoh and Shigeru Taketani and Haruki Oyaizu and Kazuya Ikebukuro and Mika Kawamura and H Genba and Tatsuya Horio and Susumu Ikehara},
  journal={Stem cells},
  volume={17 6},
The (NZW x BXSB)F1 (W/BF1) mouse is known as an autoimmune-prone strain which develops lupus nephritis, thrombocytopenia due to platelet-specific autoantibodies, leukocytosis, and myocardial infarction. In this experiment, we investigated the age-dependent abnormalities of the hematopoietic stem cells (HSCs) and hematopoiesis in this mouse. White blood cell counts (especially Mac-1- or Gr-1-positive cells) in the peripheral blood of 12-week-old W/BF1 mice increased in comparison with those of… CONTINUE READING