Age-dependent HLA genetic heterogeneity of type 1 insulin-dependent diabetes mellitus.

  title={Age-dependent HLA genetic heterogeneity of type 1 insulin-dependent diabetes mellitus.},
  author={Sophie Caillat-Zucman and Henri-Jean Garchon and Jos{\'e} Timsit and Roger Assan and Christian Boitard and I Djilali-Saiah and Pierre Bougn{\`e}res and J. F. Bach},
  journal={The Journal of clinical investigation},
  volume={90 6},
The association of insulin-dependent diabetes mellitus (IDDM) with certain HLA alleles is well documented in pediatric patients. Whether a similar association is found in adult-on-set IDDM is not clear, although the disease occurs after the age of 20 in 50% of cases. HLA class II DRB1, DQA1, and DQB1 alleles were studied in 402 type I diabetics and 405 healthy controls (all Caucasian) using oligonucleotide typing after gene amplification. Alleles DRB1*03, DRB1*04, DQB1*0201, DQB1*0302, DQA1… CONTINUE READING


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