Age-dependent, polyclonal hyperactivation of T cells is reduced in TNF-negative gld/gld mice.

Abstract

The generalized lymphoproliferative disorder (gld) mouse strain is characterized by severe splenomegaly/lymphadenopathy, the production of autoimmune antibodies, and the appearance of CD4/CD8-negative T cells. An additional TNF deficiency of gld/gld mice attenuates the course of the disorder through a yet-unknown mechanism. In this study, we could… (More)
DOI: 10.1189/jlb.0107018

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@article{Wiede2009AgedependentPH, title={Age-dependent, polyclonal hyperactivation of T cells is reduced in TNF-negative gld/gld mice.}, author={Florian Wiede and Alicia Roomberg and Erika Cretney and Anja Lechner and Phillip D Fromm and Leia H Wren and Mark J Smyth and Heinrich Koerner}, journal={Journal of leukocyte biology}, year={2009}, volume={85 1}, pages={108-16} }