Age dependency of cerebral P-gp function measured with (R)-[11C]verapamil and PET

Abstract

The aim of this study was to assess the influence of age on the functional activity of the multidrug efflux transporter P-glycoprotein (P-gp) at the human blood-brain barrier. Seven young (mean age: 27 ± 4 years) and six elderly (mean age: 69 ± 9 years) healthy volunteers underwent dynamic (R)-[11C]verapamil (VPM) positron emission tomography (PET) scans… (More)
DOI: 10.1007/s00228-009-0709-5

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