Age at onset in two common neurodegenerative diseases is genetically controlled.

  title={Age at onset in two common neurodegenerative diseases is genetically controlled.},
  author={Yi-Ju Li and William K. Scott and Dale J. Hedges and Fengyu Zhang and Perry C. Gaskell and Martha A. Nance and Ray L. Watts and Jean Pintar Hubble and William C. Koller and Rajesh Pahwa and Matthew B. Stern and Bradley C. Hiner and Joseph Jankovic and Fred A Allen and Christopher G{\"o}tz and Francis L Mastaglia and Jeffrey M. Stajich and Rachel A. Gibson and Lefkos T. Middleton and Ann M Saunders and Burton L. Scott and Gary W. Small and Kristin K Nicodemus and Allison D Reed and Donald E. Schmechel and Kathleen Welsh-Bohmer and P. Michael Conneally and A. D. Roses and John R. Gilbert and Jeffery M. Vance and Jonathan L. Haines and Margaret A. Pericak-Vance},
  journal={American journal of human genetics},
  volume={70 4},
To identify genes influencing age at onset (AAO) in two common neurodegenerative diseases, a genomic screen was performed for AAO in families with Alzheimer disease (AD; n=449) and Parkinson disease (PD; n=174). Heritabilities between 40%--60% were found in both the AD and PD data sets. For PD, significant evidence for linkage to AAO was found on chromosome 1p (LOD = 3.41). For AD, the AAO effect of APOE (LOD = 3.28) was confirmed. In addition, evidence for AAO linkage on chromosomes 6 and 10… CONTINUE READING


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