Age at onset in Sardinian bipolar I patients: evidence for three subgroups.

  title={Age at onset in Sardinian bipolar I patients: evidence for three subgroups.},
  author={Mirko Manchia and Simona F. Lampus and Caterina Chillotti and Claudia Sardu and Raffaella Ardau and Giovanni Severino and Maria Rita Del Zompo},
  journal={Bipolar disorders},
  volume={10 3},
OBJECTIVE We studied age at onset (AAO) in order to assess the presence of different subgroups in a homogeneous genetic population, such as the Sardinian population. METHODS Admixture analysis was applied in order to identify a model of separate normal distribution of AAO characterized by different means, variances and population proportions to allow for evaluation of different subgroups in a sample of 181 unrelated patients of Sardinian origin with bipolar disorder (BP) type I. The Mann… CONTINUE READING

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