Age-associated up-regulation of EGR1 promotes granulosa cell apoptosis during follicle atresia in mice through the NF-κB pathway.

@article{Yuan2016AgeassociatedUO,
  title={Age-associated up-regulation of EGR1 promotes granulosa cell apoptosis during follicle atresia in mice through the NF-κB pathway.},
  author={Suzhen Yuan and Jingyi Wen and Jing Cheng and Wei Shen and Su Yun Zhou and Weirong Yan and L i Sh{\'e}n and Aiyue Luo and Shixuan Wang},
  journal={Cell cycle},
  year={2016},
  volume={15 21},
  pages={2895-2905}
}
Follicular atresia is the main process responsible for the loss of follicles and oocytes from the ovary, and it is the root cause of ovarian aging. Apoptosis of granulosa cells (GCs) is the cellular mechanism responsible for follicular atresia in mammals. Recent advances have highlighted fundamental roles for EGR1 in age-related diseases via the induction of apoptosis. In the present study, we found that the expression of EGR1 was significantly increased in aged mouse ovaries compared with… CONTINUE READING
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