Age-associated loss of heterozygosity of tumor suppressor genes in the gastric mucosa of humans.

@article{Moragoda2002AgeassociatedLO,
  title={Age-associated loss of heterozygosity of tumor suppressor genes in the gastric mucosa of humans.},
  author={Lathika Moragoda and Richard Jaszewski and Prasad M. Kulkarni and Adhip P N Majumdar},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2002},
  volume={282 6},
  pages={
          G932-6
        }
}
The current study is based on the hypothesis that aging predisposes gastric mucosa to carcinogenesis through altered expression and/or mutations of genes involved in cell growth. To test this hypothesis, we investigated the age-associated changes in mutation of adenomatous polyposis coli (APC), deleted in colorectal cancer (DCC), p53, and K-ras genes in the gastric mucosa of 19 healthy subjects of varying ages (25-91 yr). Specifically, we studied the loss of heterozygosity (LOH) of these genes… 
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References

SHOWING 1-10 OF 56 REFERENCES
Allelic deletions of MCC/APC and p53 are frequent late events in human gastric carcinogenesis.
Loss of heterozygosity and protein expression of APC gene in renal cell carcinomas
TLDR
Results suggest that the APC tumor suppressor gene plays a role in renal carcinogenesis, but cannot be considered as a first event in tumor initiation.
Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene.
TLDR
The results strongly suggest that somatic mutations of the APC gene are associated with development of a great majority of colorectal tumors.
Frequent allelic deletion at a novel locus on chromosome 5 in human lung cancer.
Frequent loss of heterozygosity at the DCC locus in gastric cancer.
TLDR
LOH on chromosome 18q was frequent irrespective of the depth of tumor invasion, whereas the incidence of Loh on chromosome 17p was higher in the cases in which the tumor invaded beyond the muscularis propria than in those in which tumor invasion was limited to the submucosa and musculari propria.
Infrequent loss of heterozygosity at adenomatous polyposis coli gene locus in Indian oral cancers.
Genetic and epigenetic changes in stomach cancer.
Frequent loss of expression and loss of heterozygosity of the putative tumor suppressor gene DCC in prostatic carcinomas.
TLDR
It is demonstrated that loss of DCC expression and loss of heterozygosity at the DCC locus are a frequent feature of prostatic carcinoma cells.
Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas.
TLDR
The data suggest that p53 gene mutations may be involved in colorectal neoplasia, perhaps through inactivation of a tumor suppressor function of the wild-type p53 genes.
Genetic alterations underlying colorectal tumorigenesis.
  • E. Fearon
  • Medicine, Biology
    Cancer surveys
  • 1992
TLDR
A genetic model for colorectal cancer development has been proposed and, although undoubtedly incomplete, provides a useful framework for further studies of the multiple events that underlie human tumour initiation and progression.
...
1
2
3
4
5
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