Age-associated increments in human platelet alpha-adrenoceptor capacity. Possible mechanism for platelet hyperactivity to epinephrine in aging man.

@article{Yokoyama1984AgeassociatedII,
  title={Age-associated increments in human platelet alpha-adrenoceptor capacity. Possible mechanism for platelet hyperactivity to epinephrine in aging man.},
  author={Mitsuhiro Yokoyama and A Kusui and Susumu Sakamoto and Hisashi Fukuzaki},
  journal={Thrombosis research},
  year={1984},
  volume={34 4},
  pages={287-95}
}
In order to evaluate the effects of aging on platelet alpha-adrenergic receptor function, we have examined the binding of [3H]dihydroergocryptine ( [3H]DHE), a nonselective alpha-adrenergic antagonist, to crude platelet membrane at 25 degrees C in 28 subjects of various ages (mean 48, range 21-77 years) and platelet aggregatory response to epinephrine in other 32 subjects of various ages (mean 51, range 27-82 years). The average values of the binding capacity and affinity for [3H]DHE showed 218… CONTINUE READING