Age-associated increase of low-avidity cytomegalovirus-specific CD8+ T cells that re-express CD45RA.

@article{Griffiths2013AgeassociatedIO,
  title={Age-associated increase of low-avidity cytomegalovirus-specific CD8+ T cells that re-express CD45RA.},
  author={Stephen James Griffiths and Natalie E. Riddell and Joanne E Masters and Valentina Libri and Sian M. Henson and Anne M Wertheimer and Diana Wallace and Stuart Sims and Laura Rivino and Anis Larbi and David M Kemeny and Janko Nikolich-Žugich and Florian G. Kern and Paul Klenerman and Vince C. Emery and Arne N. Akbar},
  journal={Journal of immunology},
  year={2013},
  volume={190 11},
  pages={
          5363-72
        }
}
The mechanisms regulating memory CD8(+) T cell function and homeostasis during aging are unclear. CD8(+) effector memory T cells that re-express CD45RA increase considerably in older humans and both aging and persistent CMV infection are independent factors in this process. We used MHC class I tetrameric complexes that were mutated in the CD8 binding domain to identify CMV-specific CD8(+) T cells with high Ag-binding avidity. In individuals who were HLA-A*0201, CD8(+) T cells that expressed… CONTINUE READING
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