Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly

  title={Age-associated elevation in TLR5 leads to increased inflammatory responses in the elderly},
  author={F. Qian and X. Wang and L. Zhang and S. Chen and Marta Piecychna and H. Allore and L. Bockenstedt and S. Malawista and R. Bucala and A. Shaw and E. Fikrig and Ruth R. Montgomery},
  journal={Aging Cell},
  pages={104 - 110}
  • F. Qian, X. Wang, +9 authors Ruth R. Montgomery
  • Published 2012
  • Biology, Medicine
  • Aging Cell
  • Aging is accompanied by a progressive decline in immune function. Studies have shown age‐related decreases in the expression and signaling efficiency of Toll‐like receptors (TLRs) in monocytes and dendritic cells and dysregulation of macrophage TLR3. Using a multivariable mixed effect model, we report a highly significant increase in TLR5‐induced production of IL‐8 from monocytes of older individuals (P < 0.0001). Elevated IL‐8 is accompanied by increased expression of TLR5, both protein and… CONTINUE READING
    93 Citations

    Topics from this paper.

    Reduced bioenergetics and toll-like receptor 1 function in human polymorphonuclear leukocytes in aging
    • 33
    • PDF
    Flagellin-dependent TLR5/caveolin-1 as a promising immune activator in immunosenescence
    • 16
    Reduced dynamic range of antiviral innate immune responses in aging
    • 19


    Age-Associated Defect in Human TLR-1/2 Function1
    • 249
    • PDF
    Dysregulation of human Toll-like receptor function in aging
    • 130
    Age-Associated Decrease in TLR Function in Primary Human Dendritic Cells Predicts Influenza Vaccine Response
    • 366
    • PDF
    Dysregulation of TLR3 Impairs the Innate Immune Response to West Nile Virus in the Elderly
    • 150
    • PDF
    Systematic expression profiling of innate immune genes defines a complex pattern of immunosenescence in peripheral and intestinal leukocytes
    • 31
    • PDF
    Multiple control of interleukin‐8 gene expression
    • 979
    TLR5-mediated activation of p38 MAPK regulates epithelial IL-8 expression via posttranscriptional mechanism.
    • Y. Yu, H. Zeng, +4 authors A. Gewirtz
    • Medicine
    • American journal of physiology. Gastrointestinal and liver physiology
    • 2003
    • 94
    • PDF
    Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults
    • 211
    • Highly Influential
    A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses
    • 155
    • PDF
    Aging of the innate immune system.
    • 435