Age associated differences in effects of benzene on mixed-function oxidases in phenobarbital-treated rats.


These studies were performed on 5, 10, 30, 60 and 540 days old female Wistar rats. The animals were treated i.p. with phenobarbital (50 mg/kg body weight) and benzene (250 mg/kg body weight). In smooth (SER) and rough (RER) hepatic microsomes, the mixed function oxidases activity were studied. The earlier phenobarbital induction decreased the negative… (More)