• Biology, Medicine
  • Published in Journal of immunology 1996

Age-associated differences in TNF-alpha and nitric oxide production in endotoxic mice.

@article{Chorinchath1996AgeassociatedDI,
  title={Age-associated differences in TNF-alpha and nitric oxide production in endotoxic mice.},
  author={Biju Bhaskar Chorinchath and Ling Yuan Kong and Lin Chun Mao and R E Mccallum},
  journal={Journal of immunology},
  year={1996},
  volume={156 4},
  pages={
          1525-30
        }
}
Gram-negative bacterial infection is a common cause of septic shock in the older population in the U.S. We employed an experimental model of sepsis to study the cause of increased lethality due to LPS in older animals. Three ages of male B6JC3J/Nia mice, young (2 mo old), mature (12 mo old), and senescent (24 mo old), were treated with bacterial LPS, and the older mice were found to be 10 times more sensitive to LPS lethality. Increased sensitivity to LPS in senescent mice correlated with… CONTINUE READING

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