Age-associated decreased activities of mitochondrial electron transport chain complexes in heart and skeletal muscle: role of L-carnitine.

@article{Kumaran2004AgeassociatedDA,
  title={Age-associated decreased activities of mitochondrial electron transport chain complexes in heart and skeletal muscle: role of L-carnitine.},
  author={Sundaram Kumaran and Marimuthu Subathra and Muthiyah Balu and Chinnakkannu Panneerselvam},
  journal={Chemico-biological interactions},
  year={2004},
  volume={148 1-2},
  pages={11-8}
}
The mitochondrial respiratory chain is a powerful source of reactive oxygen species (ROS), considered as the pathogenic agent of many diseases and aging. L-Carnitine (4-N-trimethylammonium-3-hydroxybutric acid) plays an important role in transport of fatty acid from cytoplasm to mitochondria for energy production. Previous studies in our laboratory reported L-carnitine as a free radical scavenger in aged rats. In the present study we focused the effect of L-carnitine on the activities of… CONTINUE READING

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