Age-associated decline in mitochondrial respiration and electron transport in Drosophila melanogaster.

@article{Ferguson2005AgeassociatedDI,
  title={Age-associated decline in mitochondrial respiration and electron transport in Drosophila melanogaster.},
  author={Melissa Ferguson and Robin J. Mockett and Yi Shen and William C. Orr and Rajindar S. Sohal},
  journal={The Biochemical journal},
  year={2005},
  volume={390 Pt 2},
  pages={501-11}
}
The principal objective of the present study was to identify specific alterations in mitochondrial respiratory functions during the aging process. Respiration rates and the activities of electron transport chain complexes were measured at various ages in mitochondria isolated from thoraces of the fruit fly, Drosophila melanogaster, which consist primarily of flight muscles. The rates of state 3 respiration (ADP-stimulated), RCRs (respiratory control ratios) and uncoupled respiration rates… CONTINUE READING
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