Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus

@article{Yager2008AgeassociatedDI,
  title={Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus},
  author={E. Yager and Mushtaq Ahmed and Kathleen G Lanzer and T. Randall and D. Woodland and M. Blackman},
  journal={The Journal of Experimental Medicine},
  year={2008},
  volume={205},
  pages={711 - 723}
}
A diverse T cell repertoire is essential for a vigorous immune response to new infections, and decreasing repertoire diversity has been implicated in the age-associated decline in CD8 T cell immunity. In this study, using the well-characterized mouse influenza virus model, we show that although comparable numbers of CD8 T cells are elicited in the lung and lung airways of young and aged mice after de novo infection, a majority of aged mice exhibit profound shifts in epitope immunodominance and… Expand
Diversity and clonal selection in the human T-cell repertoire
Cytomegalovirus Exposure in the Elderly Does Not Reduce CD8 T Cell Repertoire Diversity
Impact of ageing on the response and repertoire of influenza virus-specific CD4 T cells
Early Priming Minimizes the Age-Related Immune Compromise of CD8+ T Cell Diversity and Function
The narrowing of the CD8 T cell repertoire in old age.
Loss of Naive T Cells and Repertoire Constriction Predict Poor Response to Vaccination in Old Primates
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 91 REFERENCES
Diminished T-cell response to influenza virus in aged mice.
The Influence of Age on T Cell Generation and TCR Diversity1
Age-Related Dysregulation in CD8 T Cell Homeostasis: Kinetics of a Diversity Loss1
Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity.
Response of aged mice to primary virus infections
The effect of age on the cognate function of CD4+ T cells
Hidden Epitopes Emerge in Secondary Influenza Virus-Specific CD8+ T Cell Reponses1
...
1
2
3
4
5
...